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I'd like to ask if running a condenser mic on an interface with 48v phantom power enabled (such as the focusrite pro14) at the same time with a guitar in the other input, causes any issues. There is only one button available for phantom power and it is shared across both inputs.

  • It should also be fine without a DI (using the other input as 1/4" hi-Z for the guitar), but I don't have any proof. – leftaroundabout Jan 1 '16 at 21:08
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It will be fine if you run it through a DI box for guitar.

B&H DI Box

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