The DT 770's are great headphones and are avaiable in a number of different impedences. Generally provided that the construction of the headphones is same the lower the impedence the louder the headphone will sound at the same output level, but the amount of distortion will increase. Having said that I have the 250ohm and 80ohm versions and distortion has never been an issue.
I'm not familiar with the Focusrite unit, but you might want to check the spec to see what output power/level that unit offers. It is then just simple ohms law. Increasingly manufactures are lowering the power output as headphone impedences are decreasing.